Common mechanisms of autoimmune diseases (the autoimmune tautology)

Autoimmun Rev. 2012 Sep;11(11):781-4. doi: 10.1016/j.autrev.2012.02.002. Epub 2012 Feb 12.


The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms and genetic factors has been called autoimmune tautology, and indicates that they have a common origin. The autoimmune phenotypes vary depending on the target cell and the affected organ, gender, ancestry, trigger factors and age at onset. Ten shared characteristics supporting this logical theory are herein reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Age of Onset
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / therapy
  • Autoimmunity / genetics
  • Autoimmunity / immunology
  • Environment
  • Family
  • Humans
  • Phenotype
  • Sex Factors