Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors

Ophthalmic Res. 2012;48(1):33-7. doi: 10.1159/000335983. Epub 2012 Feb 16.

Abstract

Objective: We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans.

Methods: Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression.

Results: Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels.

Conclusions: The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amine Oxidase (Copper-Containing) / metabolism*
  • Biomarkers, Tumor / metabolism*
  • Blotting, Western
  • Cell Adhesion Molecules / metabolism*
  • Conjunctiva / blood supply
  • Conjunctiva / metabolism
  • Conjunctival Neoplasms / blood supply
  • Conjunctival Neoplasms / metabolism*
  • Female
  • Fluorescent Antibody Technique, Indirect
  • Granuloma, Pyogenic / metabolism
  • Humans
  • Lymphoma, B-Cell, Marginal Zone / metabolism*
  • Male
  • Middle Aged
  • Neoplasm Proteins / metabolism*
  • Neovascularization, Pathologic / metabolism
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism

Substances

  • Biomarkers, Tumor
  • Cell Adhesion Molecules
  • Neoplasm Proteins
  • Platelet Endothelial Cell Adhesion Molecule-1
  • AOC3 protein, human
  • Amine Oxidase (Copper-Containing)