Treatment of congenital pulmonary airway malformation induced hydrops fetalis via percutaneous sclerotherapy

Fetal Diagn Ther. 2012;31(4):264-8. doi: 10.1159/000336226. Epub 2012 Feb 18.


Large type II and III congenital pulmonary airway malformations (CPAMs) can cause pulmonary hypoplasia, non-immune hydrops fetalis and fetal demise. Fetal intervention is indicated if hydrops fetalis develops. In this report, we describe three cases of type II and III CPAMs complicated by hydrops and treated with percutaneous sclerotherapy by ethanolamine injection into the tumor. All 3 cases demonstrated reduction in size of the CPAM and resolution of the hydrops with subsequent delivery at term. We believe that fetal percutaneous sclerotherapy can be used as a minimally invasive palliative strategy to treat CPAM-induced hydrops fetalis. Further studies are needed to delineate the risks of this novel technique.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cystic Adenomatoid Malformation of Lung, Congenital / complications*
  • Cystic Adenomatoid Malformation of Lung, Congenital / diagnostic imaging
  • Cystic Adenomatoid Malformation of Lung, Congenital / surgery
  • Ethanolamine / administration & dosage
  • Female
  • Gestational Age
  • Humans
  • Hydrops Fetalis / diagnostic imaging
  • Hydrops Fetalis / drug therapy*
  • Hydrops Fetalis / etiology*
  • Infant, Newborn
  • Lung / abnormalities
  • Lung / embryology
  • Lung / surgery
  • Male
  • Pregnancy
  • Sclerotherapy / methods*
  • Ultrasonography, Prenatal


  • Ethanolamine