Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques

Sci Rep. 2012:2:253. doi: 10.1038/srep00253. Epub 2012 Feb 9.


Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Animals, Newborn
  • Brain / metabolism*
  • Dependovirus / genetics*
  • Genetic Vectors*
  • Green Fluorescent Proteins / genetics
  • Macaca mulatta*
  • Transduction, Genetic*


  • Green Fluorescent Proteins