Haemostatic management of extreme challenges to haemostasis in acquired von Willebrand syndrome

Haemophilia. 2012 May;18(3):e188-91. doi: 10.1111/j.1365-2516.2012.02769.x. Epub 2012 Feb 22.


Acquired von Willebrand syndrome (AVWS) is a rare hemorrhagic condition for which very little information is available regarding the management of extreme challenges to Haemostasis. The AVWS is more common in the elderly, who are frequently exposed to invasive procedures and/or chemotherapy. Haematopoietic stem cell transplantation (HSCT) is a situation in which the haemostatic capacity is challenged by severe thrombocytopaenia, chemotherapy-associated mucosal barrier breakdown and the need for invasive procedures. In our report, we present and discuss the haemostatic management of a patient with AVWS who was refractory to Von Willebrand factor concentrate replacement during the course of an autologous HSCT to treat multiple myeloma. Patients with AVWS are frequently exposed to high-risk haemostatic challenges, and additional information about the haemostatic management of these situations is necessary.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Female
  • Hemostasis*
  • Hemostatics / therapeutic use*
  • Humans
  • Treatment Outcome
  • von Willebrand Diseases / drug therapy*
  • von Willebrand Factor / therapeutic use*


  • Hemostatics
  • von Willebrand Factor