Cyclic dipeptides exhibit potency for scavenging radicals

Tadashi Furukawa; Takashi Akutagawa; Hitomi Funatani; Toshikazu Uchida; Yoshihiro Hotta; Masatake Niwa; Yoshiaki Takaya

doi:10.1016/j.bmc.2012.01.050

Cyclic dipeptides exhibit potency for scavenging radicals

Bioorg Med Chem. 2012 Mar 15;20(6):2002-9. doi: 10.1016/j.bmc.2012.01.050. Epub 2012 Feb 3.

Authors

Tadashi Furukawa¹, Takashi Akutagawa, Hitomi Funatani, Toshikazu Uchida, Yoshihiro Hotta, Masatake Niwa, Yoshiaki Takaya

Affiliation

¹ Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.

PMID: 22356736
DOI: 10.1016/j.bmc.2012.01.050

Abstract

Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)(·-).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Dipeptides / chemistry*
Dipeptides / pharmacology*
Free Radical Scavengers / chemistry*
Free Radical Scavengers / pharmacology*
Hydroxyl Radical / metabolism
Leucine / chemistry
Leucine / pharmacology
Peptides, Cyclic / chemistry*
Peptides, Cyclic / pharmacology*
Singlet Oxygen / metabolism

Substances

Dipeptides
Free Radical Scavengers
Peptides, Cyclic
Singlet Oxygen
Hydroxyl Radical
Leucine