Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis

J Infect Dis. 2012 Apr 1;205(7):1043-7. doi: 10.1093/infdis/jis026. Epub 2012 Feb 21.


Background: We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis.

Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variables among 98 tuberculosis patients and 125 controls in Kwazulu-Natal, South Africa.

Results: Four SLC40A1 single-nucleotide polymorphisms (SNPs) were associated with an increased risk of tuberculosis and 1 SNP with reduced risk. We also found a gene-environment interaction for 4 nonexonic SNPs and iron intake.

Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cation Transport Proteins / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • South Africa
  • Tuberculosis / genetics*


  • Cation Transport Proteins
  • metal transporting protein 1