Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2012 Apr;142(4):717-23.
doi: 10.3945/jn.111.152975. Epub 2012 Feb 22.

Resistant Starch From High-Amylose Maize Increases Insulin Sensitivity in Overweight and Obese Men

Free PMC article
Clinical Trial

Resistant Starch From High-Amylose Maize Increases Insulin Sensitivity in Overweight and Obese Men

Kevin C Maki et al. J Nutr. .
Free PMC article


This study evaluated the effects of 2 levels of intake of high-amylose maize type 2 resistant starch (HAM-RS2) on insulin sensitivity (S(I)) in participants with waist circumference ≥89 (women) or ≥102 cm (men). Participants received 0 (control starch), 15, or 30 g/d (double-blind) of HAM-RS2 in random order for 4-wk periods separated by 3-wk washouts. Minimal model S(I) was assessed at the end of each period using the insulin-modified i.v. glucose tolerance test. The efficacy evaluable sample included 11 men and 22 women (mean ± SEM) age 49.5 ± 1.6 y, with a BMI of 30.6 ± 0.5 kg/m2 and waist circumference 105.3 ± 1.3 cm. A treatment main effect (P = 0.018) and a treatment × sex interaction (P = 0.033) were present. In men, least squares geometric mean analysis for S(I) did not differ after intake of 15 g/d HAM-RS2 (6.90 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹) and 30 g/d HAM-RS2 (7.13 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹), but both were higher than after the control treatment (4.66 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹) (P < 0.05). In women, there was no difference among the treatments (overall least squares ln-transformed mean ± pooled SEM = 1.80 ± 0.08; geometric mean = 6.05 × 10⁻⁵ pmol⁻¹ · L⁻¹ × min⁻¹). These results suggest that consumption of 15-30 g/d of HAM-RS2 improves S(I) in men. Additional research is needed to understand the mechanisms that might account for the treatment × sex interaction observed.

Trial registration: NCT01058135.

Conflict of interest statement

Author disclosures: K. C. Maki, K. M. Kelley, A. L. Lawless, A. L. Schild, and T. M. Rains are employees of Provident Clinical Research, which has received research grant support from National Starch, LLC, the producer of the product studied. C. L. Pelkman and E. T. Finocchiaro are employees of National Starch, LLC, the producer of the product studied.


SI following 4-wk feeding periods for control (0 g/d HAM-RS2), 15 g/d HAM-RS2, and 30 g/d HAM-RS2 in men (n = 11) and women (n = 22). Bars represent least squares geometric means and error bars extend to the value of the loge least squares mean + 1 SEM, back transformed to the original units. Labeled means without a common letter differ, P < 0.05. Least squares mean and SEM values for loge SI were generated from repeated-measures ANOVA models containing terms for participant as a random variable, treatment condition, treatment sequence, and HOMA%S. HAM-RS2, high-amylose maize type 2 resistant starch; HOMA%S, homeostasis model assessment of insulin sensitivity; SI, insulin sensitivity.

Similar articles

See all similar articles

Cited by 32 articles

See all "Cited by" articles


    1. Englyst H, Wiggins HS, Cummings JH. Determination of the non-starch polysaccharides in plant foods by gas-liquid chromatography of constituent sugars as alditol acetates. Analyst. 1982;107:307–18 - PubMed
    1. Englyst HN, Kingman SM, Cummings JH. Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr. 1992;46 Suppl 2:S33–50 - PubMed
    1. Finocchiaro ET, Birkett AM, Okoniewska M. Resistant starch. In: S Cho, P Samuel, editors. Fiber ingredients: food applications and health benefits. Boca Raton (FL): CRC Press; 2000
    1. Brown MA, Storlien LH, Brown IL, Higgins JA. Cooking attenuates the ability of high-amylose meals to reduce plasma insulin concentrations in rats. Br J Nutr. 2003;90:823–7 - PubMed
    1. Murphy MM, Douglass JS, Birkett A. Resistant starch intakes in the United States. J Am Diet Assoc. 2008;108:67–78 - PubMed

Publication types

MeSH terms

Associated data