Stimulation of cell growth in the U-937 human myeloid cell line by honey royal jelly protein

K Watanabe; H Shinmoto; M Kobori; T Tsushida; K Shinohara; J Kanaeda; M Yonekura

doi:10.1023/A:1007928408128

Stimulation of cell growth in the U-937 human myeloid cell line by honey royal jelly protein

Cytotechnology. 1998 Jan;26(1):23-7. doi: 10.1023/A:1007928408128.

Authors

K Watanabe¹, H Shinmoto, M Kobori, T Tsushida, K Shinohara, J Kanaeda, M Yonekura

Affiliation

¹ Ito-en Co. Ltd., 21 Megami, Sagara-cho, Shizuoka, 421-05, Japan.

Abstract

Royal jelly was fractionated by ion-exchange chromatography and a protein (DIII protein) that had growth stimulating activity to the U-937 human myeloid cell line was obtained. The molecular weight of the DIII protein was 58 kDa on SDS-PAGE. The growth stimulating activity of the DIII protein was shown to be relatively heat and pH stable.