Nitric oxide release: part II. Therapeutic applications

Chem Soc Rev. 2012 May 21;41(10):3742-52. doi: 10.1039/c2cs15273h. Epub 2012 Feb 24.


A wide range of nitric oxide (NO)-releasing materials has emerged as potential therapeutics that exploit NO's vast biological roles. Macromolecular NO-releasing scaffolds are particularly promising due to their ability to store and deliver larger NO payloads in a more controlled and effective manner compared to low molecular weight NO donors. While a variety of scaffolds (e.g., particles, dendrimers, and polymers/films) have been cleverly designed, the ultimate clinical utility of most NO-releasing macromolecules remains unrealized. Although not wholly predictive of clinical success, in vitro and in vivo investigations have enabled a preliminary evaluation of the therapeutic potential of such materials. In this tutorial review, we review the application of macromolecular NO therapies for cardiovascular disease, cancer, bacterial infections, and wound healing.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Blood Circulation / drug effects
  • Cardiovascular Diseases / drug therapy
  • Endothelium-Dependent Relaxing Factors / administration & dosage
  • Endothelium-Dependent Relaxing Factors / therapeutic use*
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / therapeutic use*
  • Humans
  • Neoplasms / drug therapy
  • Nitric Oxide / administration & dosage
  • Nitric Oxide / therapeutic use*
  • Reperfusion Injury / drug therapy
  • Thrombosis / drug therapy
  • Wound Healing / drug effects


  • Anti-Bacterial Agents
  • Endothelium-Dependent Relaxing Factors
  • Free Radical Scavengers
  • Nitric Oxide