Preparation of biodegradable polylactide microparticles via a biocompatible procedure

Macromol Biosci. 2012 Apr;12(4):557-66. doi: 10.1002/mabi.201100383. Epub 2012 Feb 23.


PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials
  • Drug Carriers / chemical synthesis*
  • Drug Compounding
  • Fluorescent Dyes
  • Green Chemistry Technology
  • Humans
  • Lactates / chemistry
  • Microscopy, Electron, Scanning
  • Microspheres
  • Particle Size
  • Polyesters / chemistry*
  • Porosity
  • Rhodamines
  • Solvents
  • Viscosity


  • Biocompatible Materials
  • Drug Carriers
  • Fluorescent Dyes
  • Lactates
  • Polyesters
  • Rhodamines
  • Solvents
  • poly(lactide)
  • ethyl lactate
  • rhodamine B