Polyunsaturated fatty acids and peripheral artery disease

Vasc Med. 2012 Feb;17(1):51-63. doi: 10.1177/1358863X11429175.


There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control
  • Causality
  • Comorbidity
  • Dietary Supplements*
  • Endothelial Cells / metabolism
  • Fatty Acids, Omega-3 / metabolism*
  • Fatty Acids, Omega-3 / therapeutic use*
  • Fatty Acids, Omega-6 / metabolism
  • Fatty Acids, Unsaturated / metabolism*
  • Fish Oils / metabolism
  • Humans
  • Monocytes / metabolism
  • Peripheral Arterial Disease / epidemiology
  • Peripheral Arterial Disease / metabolism*
  • Peripheral Arterial Disease / prevention & control*
  • Secondary Prevention


  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6
  • Fatty Acids, Unsaturated
  • Fish Oils