Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head

Ophthalmology. 2012 Jun;119(6):1151-8. doi: 10.1016/j.ophtha.2011.12.014. Epub 2012 Feb 23.


Purpose: To determine the diagnostic performance of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with the Cirrus high-definition optical coherence tomography (HD-OCT) ganglion cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements.

Design: Evaluation of diagnostic test or technology.

Participants: Fifty-eight patients with early glaucoma and 99 age-matched normal subjects.

Methods: Macular GCIPL and peripapillary RNFL thicknesses and ONH parameters were measured in each participant, and their diagnostic abilities were compared.

Main outcome measures: Area under the curve (AUC) of the receiver operating characteristic.

Results: The GCIPL parameters with the best AUCs were the minimum (0.959), inferotemporal (0.956), average (0.935), superotemporal (0.919), and inferior sector (0.918). There were no significant differences between these AUCs and those of inferior quadrant (0.939), average (0.936), and superior quadrant RNFL (0.933); vertical cup-to-disc diameter ratio (0.962); cup-to-disc area ratio (0.933); and rim area (0.910), all P>0.05.

Conclusions: The ability of macular GCIPL parameters to discriminate normal eyes and eyes with early glaucoma is high and comparable to that of the best peripapillary RNFL and ONH parameters.

Financial disclosure(s): Proprietary or commercial disclosure may be found after the references.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Area Under Curve
  • Axons / pathology*
  • Cross-Sectional Studies
  • False Positive Reactions
  • Female
  • Glaucoma / diagnosis*
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Optic Disk / pathology*
  • Optic Nerve Diseases / diagnosis*
  • Predictive Value of Tests
  • ROC Curve
  • Reproducibility of Results
  • Retinal Ganglion Cells / pathology*
  • Sensitivity and Specificity
  • Tomography, Optical Coherence