Sound-driven synaptic inhibition in primary visual cortex

Neuron. 2012 Feb 23;73(4):814-28. doi: 10.1016/j.neuron.2011.12.026.


Multimodal objects and events activate many sensory cortical areas simultaneously. This is possibly reflected in reciprocal modulations of neuronal activity, even at the level of primary cortical areas. However, the synaptic character of these interareal interactions, and their impact on synaptic and behavioral sensory responses are unclear. Here, we found that activation of auditory cortex by a noise burst drove local GABAergic inhibition on supragranular pyramids of the mouse primary visual cortex, via cortico-cortical connections. This inhibition was generated by sound-driven excitation of a limited number of cells in infragranular visual cortical neurons. Consequently, visually driven synaptic and spike responses were reduced upon bimodal stimulation. Also, acoustic stimulation suppressed conditioned behavioral responses to a dim flash, an effect that was prevented by acute blockade of GABAergic transmission in visual cortex. Thus, auditory cortex activation by salient stimuli degrades potentially distracting sensory processing in visual cortex by recruiting local, translaminar, inhibitory circuits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Action Potentials / genetics
  • Action Potentials / physiology
  • Analysis of Variance
  • Animals
  • Bacterial Proteins / genetics
  • Channelrhodopsins
  • Conditioning, Classical
  • GABA Antagonists / pharmacology
  • Luminescent Proteins / genetics
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neural Inhibition / drug effects
  • Neural Inhibition / physiology*
  • Neurons / drug effects
  • Neurons / physiology*
  • Phosphinic Acids / pharmacology
  • Photic Stimulation
  • Picrotoxin / pharmacology
  • Propanolamines / pharmacology
  • Psychophysics
  • Statistics, Nonparametric
  • Visual Cortex / cytology
  • Visual Cortex / drug effects
  • Visual Cortex / physiology*
  • Wakefulness


  • Bacterial Proteins
  • Channelrhodopsins
  • GABA Antagonists
  • Luminescent Proteins
  • Phosphinic Acids
  • Propanolamines
  • yellow fluorescent protein, Bacteria
  • Picrotoxin
  • CGP 55845A