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Randomized Controlled Trial
, 57 (6), 1609-17

A Study on the Efficacy of Rebamipide for Patients With Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease

Randomized Controlled Trial

A Study on the Efficacy of Rebamipide for Patients With Proton Pump Inhibitor-Refractory Non-Erosive Reflux Disease

Kyoichi Adachi et al. Dig Dis Sci.


Background and aim: Reflux symptoms in patients with non-erosive reflux disease (NERD) cannot be easily controlled by treatment with proton pump inhibitors (PPI). The anti-inflammatory function of rebamipide may be effective for protecting the esophageal mucosa. This prospective randomized multicenter placebo-controlled study was performed to clarify the efficacy of rebamipide for NERD patients whose reflux symptoms were refractory to PPI treatment.

Methods: One hundred forty-nine patients were enrolled on the basis of a QUEST score of over 6 and absence of endoscopically proven esophageal mucosal breaks. All the patients were initially administered 15 mg of lansoprazole for 4 weeks, and the symptoms were then assessed using QUEST and GSRS. PPI-refractory patients were randomly assigned to administration of rebamipide or placebo t.i.d. for 4 weeks.

Results: Three of the 149 patients were lost to follow-up, and 60 among the remaining 146 patients were found to be PPI-refractory. Among these PPI-refractory patients, 31 were randomly assigned to a rebamipide group and 29 to a placebo group. At the end of drug administration, the QUEST and GSRS scores did not differ between the rebamipide and placebo groups, although a significantly higher proportion of patients in the rebamipide group showed amelioration of abdominal pain and diarrhea.

Conclusion: Administration of rebamipide cannot effectively control reflux symptoms in NERD patients whose symptoms are refractory to PPI therapy.

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    1. Scand J Gastroenterol Suppl. 1993;199:18-21 - PubMed
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    1. J Gastroenterol Hepatol. 2001 Feb;16(2):132-6 - PubMed
    1. Aliment Pharmacol Ther. 1997 Aug;11(4):755-63 - PubMed
    1. Eur J Pharmacol. 1992 Feb 25;212(1):9-13 - PubMed

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