Nesfatin-1 and other hormone alterations in polycystic ovary syndrome

Endocrine. 2012 Dec;42(3):694-9. doi: 10.1007/s12020-012-9638-7. Epub 2012 Feb 25.


Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index
  • Calcium-Binding Proteins / metabolism*
  • DNA-Binding Proteins / metabolism*
  • Female
  • Hormones / metabolism*
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Lipids / blood
  • Nerve Tissue Proteins / metabolism*
  • Nucleobindins
  • Polycystic Ovary Syndrome / metabolism*
  • Young Adult


  • Blood Glucose
  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • Hormones
  • Insulin
  • Lipids
  • NUCB2 protein, human
  • Nerve Tissue Proteins
  • Nucleobindins