Abstract
We describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amides / chemistry*
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Carboxylic Acids / chemistry
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Cyclosporine / chemical synthesis
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Cyclosporine / chemistry
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Glycopeptides / chemical synthesis
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Glycopeptides / chemistry
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry
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Nitriles / chemistry*
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Peptides / chemical synthesis
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Peptides / chemistry
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Stereoisomerism
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Sulfhydryl Compounds / chemistry
Substances
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Amides
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Carboxylic Acids
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Glycopeptides
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Heterocyclic Compounds
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Nitriles
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Peptides
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Sulfhydryl Compounds
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Cyclosporine