A(2A)/D(2) receptor heteromerization in a model of Parkinson's disease. Focus on striatal aminoacidergic signaling

Brain Res. 2012 Oct 2;1476:96-107. doi: 10.1016/j.brainres.2012.01.032. Epub 2012 Jan 24.

Abstract

The present manuscript mainly summarizes the basic concepts and the molecular mechanisms underlying adenosine A(2A)-dopamine D(2) receptor-receptor interactions in the basal ganglia. Special emphasis is placed on neurochemical, behavioral and electrophysiological findings supporting the functional role that A(2A)/D(2) heteromeric receptor complexes located on striato-pallidal GABA neurons and corticostriatal glutamate terminals play in the regulation of the so called "basal ganglia indirect pathway". Furthermore, the role of A(2A)/mGluR(5) synergistic interactions in striatal neuron function and dysfunction is discussed. The functional consequences of the interactions between striatal adenosine A(2A), mGluR(5) and dopamine D(2) receptors on striatopallidal GABA release and motor behavior dysfunctions suggest the possibility of simultaneously targeting these receptors in Parkinson's disease treatment. This article is part of a Special Issue entitled Brain Integration. This article is part of a Special Issue entitled: Brain Integration.

Publication types

  • Review

MeSH terms

  • Amino Acids / metabolism*
  • Animals
  • Corpus Striatum / metabolism*
  • Humans
  • Models, Biological
  • Parkinson Disease* / genetics
  • Parkinson Disease* / metabolism
  • Parkinson Disease* / pathology
  • Receptor, Adenosine A2A / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Signal Transduction / genetics*

Substances

  • Amino Acids
  • Receptor, Adenosine A2A
  • Receptors, Dopamine D2