A retrospective analysis of the management of freckles and lentigines using four different pigment lasers on Asian skin

J Cosmet Laser Ther. 2012 Apr;14(2):74-80. doi: 10.3109/14764172.2012.670707.


Background: The risk of post-inflammatory hyperpigmentation (PIH) is increased during freckles and lentigines treatment in Asians.

Objective: To determine the effectiveness and safety of using 595-nm long pulsed dye laser (LPDL), 755-nm LP Alexandrite laser, 532-nm QS Nd:YAG laser and 532-nm LP potassium-titanyl-phosphate (KTP) laser for the treatment of freckles or lentigines in Asian patients.

Methods: This is a retrospective study of 40 Chinese patients, who were divided into four groups based on treatment modality using four different pigment lasers. Each patient attended between 1 and 4 treatments (mean of 1.8), at 4-6 weeks intervals, depending on clinical response. Lesional clearance and PIH were assessed by two independent clinicians.

Results: Statistically significant improvement of global and focal facial pigmentation was found after treatment with LPDL, QS Nd:YAG and LP KTP lasers. No significant improvement was found after LP Alexandrite laser. PIH risk was 20% after LP Alexandrite treatment, 10% with QS Nd:YAG, and absent after LPDL and LP KTP treatment.

Conclusion: A long pulse laser and small spot size appear to reduce the risks of lentigines treatment in darker skin types.

MeSH terms

  • Adult
  • Asian People*
  • Female
  • Humans
  • Hyperpigmentation / ethnology
  • Hyperpigmentation / etiology
  • Lasers, Dye / adverse effects
  • Lasers, Dye / therapeutic use*
  • Lasers, Solid-State / adverse effects
  • Lasers, Solid-State / therapeutic use*
  • Lentigo / ethnology
  • Lentigo / therapy
  • Melanosis / ethnology
  • Melanosis / therapy*
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult