Effects of a provincial ban of two toxic organophosphorus insecticides on pesticide poisoning hospital admissions

Clin Toxicol (Phila). 2012 Mar;50(3):202-9. doi: 10.3109/15563650.2012.660573.

Abstract

Background: Pesticide self-poisoning causes one third of global suicides. Sri Lanka halved its suicide rate by banning WHO Class I organophosphorus (OP) insecticides and then endosulfan. However, poisoning with Class II toxicity OPs, particularly dimethoate and fenthion, remains a problem. We aimed to determine the effect and feasibility of a ban of the two insecticides in one Sri Lankan district.

Methods: Sale was banned in June 2003 in most of Polonnaruwa District, but not Anuradhapura District. Admissions with pesticide poisoning to the district general hospitals was prospectively recorded from 2002.

Results: Hospital admissions for dimethoate and fenthion poisoning fell by 43% after the ban in Polonnaruwa, while increasing by 23% in Anuradhapura. The pesticide case fatality fell from 14.4% to 9.0% in Polonnaruwa (odds ratio [OR] 0.59, 95% confidence interval [CI] 0.41-0.84) and 11.3% to 10.6% in Anuradhapura (OR 0.93, 95%CI 0.70-1.25; p = 0.051). This reduction was not sustained, with case fatality in Polonnaruwa rising to 12.1% in 2006-2007. Further data analysis indicated that the fall in case fatality had actually been due to a coincidental reduction in case fatality for pesticide poisoning overall, in particular for paraquat poisoning.

Conclusions: We found that the insecticides could be effectively banned from agricultural practice, as shown by the fall in hospital admissions, with few negative consequences. However, the ban had only a minor effect on pesticide poisoning deaths because it was too narrow. A study assessing the agricultural and health effects of a more comprehensive ban of highly toxic pesticides is necessary to determine the balance between increased costs of agriculture and reduced health care costs and fewer deaths.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agriculture / legislation & jurisprudence*
  • Commerce / legislation & jurisprudence
  • Government Regulation*
  • Health Policy / legislation & jurisprudence*
  • Hospitalization
  • Humans
  • Incidence
  • Organophosphate Poisoning*
  • Organophosphorus Compounds / supply & distribution
  • Pesticides / poisoning*
  • Pesticides / supply & distribution
  • Poisoning / epidemiology
  • Poisoning / etiology*
  • Poisoning / prevention & control
  • Sri Lanka / epidemiology

Substances

  • Organophosphorus Compounds
  • Pesticides