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. 2012 Feb 28;11:32.
doi: 10.1186/1476-511X-11-32.

Serum Contents of Endocannabinoids Are Correlated With Blood Pressure in Depressed Women

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Free PMC article

Serum Contents of Endocannabinoids Are Correlated With Blood Pressure in Depressed Women

W S Vanessa Ho et al. Lipids Health Dis. .
Free PMC article

Abstract

Background: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in both cardiovascular function and depression, we asked whether endocannabinoids correlated with either in humans.

Results: Resting blood pressure and serum content of endocannabinoids in ambulatory, medication-free, female volunteers with depression (n = 28) and their age- and ethnicity-matched controls (n = 27) were measured. In females with depression, both diastolic and mean arterial blood pressures were positively correlated with serum contents of the endocannabinoids, N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol. There was no correlation between blood pressure and endocannabinoids in control subjects. Furthermore, depressed women had significantly higher systolic blood pressure than control subjects. A larger body mass index was also found in depressed women, however, it was not significantly correlated with serum endocannabinoid contents.

Conclusions: This preliminary study raises the possibility that endocannabinoids play a role in blood pressure regulation in depressives with higher blood pressure, and suggests an interrelationship among endocannabinoids, depression and cardiovascular risk factors in women.

Figures

Figure 1
Figure 1
Scatter plots of serum content of N-arachidonylethanolamide (AEA) and mean or diastolic blood pressure in control (a, b) or depressed subjects (c, d). n = 27-28. Serum AEA is positively correlated with mean (r = .50) and diastolic blood pressure (r = .46) in depressed subjects (c.f. Table 2).
Figure 2
Figure 2
Scatter plots of serum content of 2-arachidonoylglycerol (2-AG) and mean or diastolic blood pressure in control (a, b) or depressed subjects (c, d). n = 27-28. Serum 2-AG is positively correlated with mean (r = .46) and diastolic pressure (r = .62) in depressed subjects (c.f. Table 2).

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