A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells

Chem Commun (Camb). 2012 Apr 7;48(28):3388-90. doi: 10.1039/c2cc00029f. Epub 2012 Feb 28.

Abstract

The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Angiogenesis Inhibitors / toxicity*
  • Animals
  • Cell Line
  • Cell Survival / drug effects
  • Endoplasmic Reticulum / drug effects*
  • Endoplasmic Reticulum / pathology
  • Endoplasmic Reticulum Stress / drug effects
  • HeLa Cells
  • Humans
  • Mice
  • Organogold Compounds / pharmacology
  • Organogold Compounds / toxicity*
  • Solubility
  • Water / chemistry

Substances

  • Angiogenesis Inhibitors
  • Organogold Compounds
  • Water