Potential impact of accelerating the primary dose of rotavirus vaccine in infants

Vaccine. 2012 Apr 5;30(17):2738-41. doi: 10.1016/j.vaccine.2012.02.032. Epub 2012 Feb 26.


We estimated the potential impact of administering the first dose of rotavirus vaccine at 6 weeks (42 days of life) instead of 2 months of age, which is permissible for all U.S. vaccines recommended at 2 months of age, on rotavirus hospitalization rates. We used published data for hospitalization rates, vaccine coverage, and vaccine efficacy after one dose and assumed a two-week delay in seroconversion after vaccine administration in the United States. Administering the first dose of rotavirus vaccine at 6 weeks instead of 8 weeks of age should have prevented 1110, 1660, and 2210 rotavirus hospitalizations among U.S. infants <3 months of age in 2006 when the vaccine was first introduced. This estimated benefit represents a 2-4% reduction in rotavirus hospitalizations among children <5 years of age.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Gastroenteritis / immunology
  • Gastroenteritis / prevention & control
  • Hospitalization
  • Humans
  • Immunization Schedule
  • Infant
  • Rotavirus Infections / immunology
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / administration & dosage*
  • Rotavirus Vaccines / immunology
  • United States


  • Rotavirus Vaccines