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, 6 (1), 118-21

A Case of Synchronous Squamous Cell Carcinoma in the Esophagus and Stomach


A Case of Synchronous Squamous Cell Carcinoma in the Esophagus and Stomach

Sun Min Lim et al. Gut Liver.


Synchronous esophageal and gastric cancers with the pathologic features of a squamous cell carcinoma are extremely rare. A 57-year-old male visited our hospital with a history of hematemesis and was diagnosed with a synchronous cancer. He underwent a staging work-up, and the resectable lesion in the stomach was operated on following radiologic and endoscopic evaluations. The pathologic examination revealed a synchronous cancer consisting of squamous cell carcinoma in the distal esophagus and the cardia of the stomach. We report a case of a synchronous cancer that was successfully treated by surgical resection followed by concurrent chemoradiotherapy. We also discuss the hypothesis regarding the origin and presentation of the synchronous cancer and highlight the importance of careful surveillance by physicians at the time of diagnosis.

Keywords: Esophageal neoplasms; Stomach neoplasms; Synchronous.

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.


Fig. 1
Fig. 1
(A) An abdominopelvic computed tomography shows an ulcerofungating mass at the gastric fundus (B) that extended to the esophagogastric junction and distal esophagus with serosal exposure.
Fig. 2
Fig. 2
(A) Microscopic findings of invasive squamous cell carcinoma obtained from the esophagus (H&Estain, ×40). (B) The lesion is poorly differentiated (H&E stain, ×200).
Fig. 3
Fig. 3
(A) The cancer mucosa compared to the normal mucosa obtained from the lesser curvature of the upper body of the stomach (H&Estain, ×40). (B) The invasive squamous cell carcinoma of the stomach is moderately differentiated (H&Estain, ×200).
Fig. 4
Fig. 4
A gross specimen from the stomach after total gastrectomy, pT4N2M0. There is an ulcerofungating mass measuring 6×6 cm in the lesser curvature of the cardia. It is located 1.3 cm from the proximal resection margin and 12.5 cm from the distal resection margin. Both the proximal and distal resection margins are shown to be free of carcinoma (a safety margin of 1.3 cm and a safety margin of 12.5 cm, respectively).

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