Case report: atypical lipomatous tumor with unusual extensive metaplastic ossification

Cancer Imaging. 2012;12(1):25-30. doi: 10.1102/1470-7330.2012.0004.

Abstract

The presence of metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence. When present, bone formation is most often found in association with a dedifferentiated component arising within the primary tumor. It is important for the radiologist not only to recognize the differential diagnosis of a calcified or ossified soft tissue mass but also be aware of the various soft tissue neoplasms, both aggressive and non-aggressive, that may show such features. We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy, Needle
  • Cyclin-Dependent Kinase 4 / analysis
  • Diagnosis, Differential
  • Humans
  • Liposarcoma / chemistry
  • Liposarcoma / complications
  • Liposarcoma / diagnostic imaging*
  • Liposarcoma / pathology
  • Liposarcoma / surgery
  • Magnetic Resonance Imaging*
  • Male
  • Metaplasia
  • Ossification, Heterotopic / diagnostic imaging*
  • Ossification, Heterotopic / etiology
  • Ossification, Heterotopic / pathology
  • Positron-Emission Tomography*
  • Proto-Oncogene Proteins c-mdm2 / analysis
  • Radiography, Interventional
  • Radiopharmaceuticals
  • Shoulder
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / complications
  • Soft Tissue Neoplasms / diagnostic imaging*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / surgery
  • Technetium Tc 99m Medronate
  • Tomography, X-Ray Computed

Substances

  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • CDK4 protein, human
  • Cyclin-Dependent Kinase 4
  • Technetium Tc 99m Medronate