Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection

J Invest Dermatol. 2012 May;132(5):1513-6. doi: 10.1038/jid.2011.462. Epub 2012 Mar 1.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • ADAM Proteins / antagonists & inhibitors
  • ADAM Proteins / genetics*
  • ADAM10 Protein
  • Amyloid Precursor Protein Secretases / antagonists & inhibitors
  • Amyloid Precursor Protein Secretases / genetics*
  • Animals
  • Bacterial Toxins / metabolism
  • Cadherins / metabolism
  • Cells, Cultured
  • Dipeptides / pharmacology
  • Hemolysin Proteins / metabolism
  • Hydroxamic Acids / pharmacology
  • Keratinocytes / metabolism
  • Membrane Proteins / antagonists & inhibitors
  • Membrane Proteins / genetics*
  • Metalloproteases / metabolism
  • Mice
  • Mice, Knockout
  • Necrosis / metabolism
  • Skin / drug effects
  • Skin / pathology*
  • Skin / physiopathology*
  • Staphylococcal Skin Infections / genetics*
  • Staphylococcal Skin Infections / metabolism
  • Staphylococcal Skin Infections / pathology
  • Staphylococcus aureus / metabolism
  • Staphylococcus aureus / pathogenicity*

Substances

  • 3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide
  • Bacterial Toxins
  • Cadherins
  • Dipeptides
  • Hemolysin Proteins
  • Hydroxamic Acids
  • Membrane Proteins
  • staphylococcal alpha-toxin
  • Amyloid Precursor Protein Secretases
  • Metalloproteases
  • ADAM Proteins
  • ADAM10 Protein
  • Adam10 protein, mouse