Abstract
Aberrant nuclear factor-erythroid 2 (NRF2) expression correlates with tumor development. We investigated NRF2 expression in ovarian epithelial carcinoma (OEC), aiming to identify associations with clinicopathological factors, hormones and induced reactive oxygen species (ROS). Immunohistochemical staining for NRF2 expression was performed on 10 benign cystadenomas, 4 boderline tumors and 64 OECs. Western blotting was used to determine the effects of hormones on NRF2 expression in OEC. NRF2 protein was found to be overexpressed in OEC. Gonadotrophins and estrogen induced ROS production in OEC; these hormones also enhanced NRF2 expression. Therefore, aberrant expression may be induced by hormones through ROS signaling. Increased NRF2 expression may be a molecular event in OEC carcinogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Carcinoma, Ovarian Epithelial
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Cell Line, Tumor
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Cystadenoma / metabolism
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Estradiol / metabolism
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Estradiol / pharmacology
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Female
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Follicle Stimulating Hormone / metabolism
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Follicle Stimulating Hormone / pharmacology
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Gonadal Steroid Hormones / metabolism*
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Gonadal Steroid Hormones / pharmacology
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Gonadotropins / metabolism*
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Humans
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Luteinizing Hormone / metabolism
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Luteinizing Hormone / pharmacology
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Medroxyprogesterone / metabolism
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Medroxyprogesterone / pharmacology
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Middle Aged
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NF-E2-Related Factor 2 / biosynthesis*
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Neoplasms, Glandular and Epithelial / genetics
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Neoplasms, Glandular and Epithelial / metabolism*
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Neoplasms, Glandular and Epithelial / pathology*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / metabolism*
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Ovarian Neoplasms / pathology*
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Oxidative Stress
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Reactive Oxygen Species / metabolism
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Signal Transduction
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Young Adult
Substances
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Gonadal Steroid Hormones
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Gonadotropins
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Reactive Oxygen Species
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Estradiol
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Luteinizing Hormone
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Follicle Stimulating Hormone
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Medroxyprogesterone