The role and impact of research agendas on the comparative-effectiveness research among antihyperlipidemics

Clin Pharmacol Ther. 2012 Apr;91(4):685-91. doi: 10.1038/clpt.2011.279. Epub 2012 Feb 29.


Although it is well established that funding source influences the publication of clinical trials, relatively little is known about how funding influences trial design. We examined a public trial registry to determine how funding source shapes trial design among trials involving antihyperlipidemics. We used an automated process to identify and analyze 809 trials from a set of 72,564. Three networks representing industry-, collaboratively, and non-industry-funded trials were constructed. Each network comprised 18 drugs as nodes connected according to the number of comparisons made between them. The results indicated that industry-funded trials were more likely to compare across drugs and examine dyslipidemia as a condition, and less likely to register safety outcomes. The source of funding for clinical trials had a measurable effect on trial design, which helps quantify differences in research agendas. Improved monitoring of current clinical trials may be used to more closely align research agendas to clinical needs.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic / economics
  • Clinical Trials as Topic / methods*
  • Comparative Effectiveness Research / economics
  • Comparative Effectiveness Research / methods*
  • Humans
  • Hypolipidemic Agents / economics
  • Hypolipidemic Agents / therapeutic use*
  • Random Allocation
  • Registries*
  • Research Design


  • Hypolipidemic Agents