Protein-protein interaction inhibitors get into the groove

Nat Rev Drug Discov. 2012 Mar 1;11(3):173-5. doi: 10.1038/nrd3680.
No abstract available

Publication types

  • News

MeSH terms

  • Animals
  • Binding Sites / drug effects
  • Binding Sites / physiology
  • Drug Discovery / trends
  • Humans
  • Protein Binding / drug effects
  • Protein Binding / physiology
  • Protein Interaction Domains and Motifs / drug effects
  • Protein Interaction Domains and Motifs / physiology*
  • Pyrroles / metabolism*
  • Pyrroles / pharmacology
  • bcl-X Protein / antagonists & inhibitors
  • bcl-X Protein / metabolism

Substances

  • BCL2L1 protein, human
  • Pyrroles
  • bcl-X Protein
  • obatoclax