Paediatric anticoagulation guidelines

S Afr Med J. 2012 Feb 23;102(3 Pt 1):171-5. doi: 10.7196/samj.5471.


Prepared on behalf of the South African Society of Thombosis and Haemostasis. Background. Recent progress has been made in the understanding of venous thrombo-embolism (VTE) in children and neonates; however, indications for laboratory investigations and therapeutic interventions are not well defined. Method. The Southern African Society of Thrombosis and Haemostasis reviewed available literature and comprehensive evidence-based guidelines for paediatric antithrombotic therapy. A draft document was produced and revised by consensus agreement. The guidelines were adjudicated by independent international experts to avoid local bias. Results and conclusion. We present concise, practical guidelines for the clinical management and laboratory investigation of VTE in children and neonates. Recommendations reflect current best practice which will hopefully lead to improved anticoagulation practice in this age group.

Publication types

  • Practice Guideline

MeSH terms

  • Anticoagulants* / administration & dosage
  • Anticoagulants* / adverse effects
  • Blood Coagulation / drug effects
  • Child
  • Disease Management
  • Drug Monitoring / methods*
  • Hemorrhage / chemically induced
  • Hemorrhage / therapy
  • Humans
  • Infant
  • Venous Thromboembolism* / diagnosis
  • Venous Thromboembolism* / drug therapy
  • Venous Thromboembolism* / etiology
  • Venous Thromboembolism* / physiopathology
  • Warfarin / administration & dosage
  • Warfarin / adverse effects


  • Anticoagulants
  • Warfarin