Intravenous lipid emulsion (ILE) infusions have become an emerging treatment modality in managing intoxications of veterinary patients. The advantages of ILE include an apparent wide margin of safety, relatively low cost, long shelf-life, and ease of administration. Based on limited case and anecdotal reports, ILEs have shown promise in the management of toxicoses from a variety of lipophilic agents, including drugs and pesticides. More studies are needed to determine optimum dosing regimens and identify potential adverse effects from the antidotal use of ILE in veterinary medicine.