Management of attention-deficit disorder and attention-deficit/hyperactivity disorder drug intoxication in dogs and cats

Vet Clin North Am Small Anim Pract. 2012 Mar;42(2):279-87, vi. doi: 10.1016/j.cvsm.2012.01.004.


Two types of drugs are generally used for treating attention-deficit/hyperactivity disorder or attention-deficit disorder in humans: amphetamines or similar stimulants and the nonamphetamine atomoxetine. We describe the toxicity and treatment of both amphetamines and similar medications and atomoxetine in dogs and cats. Amphetamine intoxication can cause life-threatening stimulatory signs. Treatment is aimed at preventing absorption, controlling the stimulatory signs, and protecting the kidneys; prognosis is generally good. Atomoxetine also has a fast onset of action; stimulatory signs such as hyperactivity and tachycardia are often seen. There are little published data about treatment of atomoxetine toxicity in cats and dogs.

Publication types

  • Review

MeSH terms

  • Adrenergic Uptake Inhibitors / antagonists & inhibitors
  • Adrenergic Uptake Inhibitors / poisoning*
  • Amphetamines / antagonists & inhibitors
  • Amphetamines / poisoning
  • Animals
  • Atomoxetine Hydrochloride
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Cat Diseases / chemically induced
  • Cat Diseases / diagnosis
  • Cat Diseases / therapy*
  • Cats
  • Central Nervous System Stimulants / antagonists & inhibitors
  • Central Nervous System Stimulants / poisoning*
  • Dog Diseases / chemically induced
  • Dog Diseases / diagnosis
  • Dog Diseases / therapy*
  • Dogs
  • Humans
  • Poison Control Centers / statistics & numerical data
  • Propylamines / antagonists & inhibitors
  • Propylamines / poisoning


  • Adrenergic Uptake Inhibitors
  • Amphetamines
  • Central Nervous System Stimulants
  • Propylamines
  • Atomoxetine Hydrochloride