[Antibiotic resistance of Gardnerella vaginalis isolated from cases of bacterial vaginosis]

Ginekol Pol. 2011 Dec;82(12):900-4.
[Article in Polish]

Abstract

Introduction: Gardnerella vaginalis is one of the dominant etiological factors related to bacterial vaginosis. Literature offers a growing number of reports revealing there appear Gardnerella vaginalis strains increasingly resistant to metronidazole.

Objectives: The aim of this study was to determine the susceptibility of Gardnerella vaginalis strains isolated from women with bacterial vaginosis to metronidazole, clindamycin and amoxicillin/clavulanic acid.

Material and methods: The investigation was performed on collection of 67 Gardnerella vaginalis strains isolated from the group of 604 women participating in the study Antibiotic sensitivity of strains was verified by E-test method (BioMerieux). Interpretation of results was performed in accordance with EUCAST criteria.

Results: All tested strains, apart from one, were sensitive to clindamycin and amoxicillin/clavulanic acid. The results of susceptibility test to metronidazole indicated that 68.7% (46 out of 67 strains) were resistant to this antibiotic, while all of them were sensitive to both clindamycin and amoxicillin/clavulanic acid.

Conclusions: Near future may bring the need to change the treatment regimen of bacterial vaginosis.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Administration, Intravaginal
  • Administration, Oral
  • Adult
  • Amoxicillin-Potassium Clavulanate Combination / pharmacology
  • Anti-Infective Agents / pharmacology*
  • Bacterial Typing Techniques
  • Clindamycin / pharmacology
  • Drug Resistance, Bacterial*
  • Female
  • Gardnerella vaginalis / drug effects*
  • Gardnerella vaginalis / isolation & purification
  • Humans
  • Metronidazole / pharmacology
  • Microbial Sensitivity Tests
  • Middle Aged
  • Poland / epidemiology
  • Vagina / microbiology
  • Vaginosis, Bacterial / drug therapy*
  • Vaginosis, Bacterial / microbiology*
  • Young Adult

Substances

  • Anti-Infective Agents
  • Metronidazole
  • Clindamycin
  • Amoxicillin-Potassium Clavulanate Combination