Four patients (one man and 3 women) with generalized form of Behçet's syndrome with 3-7 years duration were followed up. Prior admission to the clinic the patients had been treated symptomatically, two of them with cyclophosphamide and one patient with corticosteroids without effect. In the clinic they were treated with Azathioprin 2 mg/kg body mass. At the end of the second month remission of the disease was registered in all four patients which lasts without discontinuing the treatment in one of the patients 7 years, in the second patient--4 years, in the third patient--3 years and in the fourth patient--2 years. The supporting treatment is 1 mg/kg body mass of Azathioprin which begins at the end of the first year after achieving a stable clinical remission. No side effects were observed.