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Review
. 2012 Mar;129(3 Suppl):S136-41.
doi: 10.1016/j.jaci.2011.12.987.

Mediators of asthma outcomes

Cynthia S Rand  1 , Rosalind J Wright, Michael D Cabana, Michael B Foggs, Jill S Halterman, Lynn Olson, William M Vollmer, Sandra R Wilson, Virginia Taggart
Affiliations
Review

Mediators of asthma outcomes

Cynthia S Rand et al. J Allergy Clin Immunol. 2012 Mar.

Abstract

Background: Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators.

Objective: National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators.

Methods: We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature.

Results: The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants.

Conclusions: Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.

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