Historical Review, Epidemiology and Natural History of Degenerative Mitral Valve Disease

J Vet Cardiol. 2012 Mar;14(1):93-101. doi: 10.1016/j.jvc.2012.01.011. Epub 2012 Mar 3.


Chronic mitral valve disease due to myxomatous degeneration (MMVD) is the most common cardiovascular disease in dogs and has been known to cause congestive heart failure for more than 100 years. This article presents an historical perspective of the disease and reviews the most updated data on epidemiology and natural history of MMVD in dogs.

Publication types

  • Review

MeSH terms

  • Aging
  • Animals
  • Dog Diseases / epidemiology*
  • Dog Diseases / genetics
  • Dog Diseases / pathology
  • Dogs
  • Mitral Valve Insufficiency / epidemiology
  • Mitral Valve Insufficiency / genetics
  • Mitral Valve Insufficiency / pathology
  • Mitral Valve Insufficiency / veterinary*