Mitochondrial regulation of CRAC channel-driven cellular responses

Cell Calcium. 2012 Jul;52(1):52-6. doi: 10.1016/j.ceca.2012.02.003. Epub 2012 Mar 3.


One widespread and conserved Ca(2+) entry pathway in eukaryotic cells is the store-operated CRAC channel and Ca(2+) entry through these channels activates a disparate array of cellular responses. Under physiological conditions, mitochondria are important regulators of CRAC channel gating. Through these actions, mitochondria help control a range of spatially and temporally distinct CRAC channel-driven responses including enzyme activation, secretion, intercellular communication through paracrine signals and gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcium / metabolism
  • Calcium Channels / metabolism*
  • Calcium Signaling
  • Enzyme Activation
  • Humans
  • MAP Kinase Kinase Kinases / metabolism
  • Membrane Proteins / metabolism
  • Mitochondria / metabolism*
  • Neoplasm Proteins / metabolism
  • Stromal Interaction Molecule 1


  • Calcium Channels
  • Membrane Proteins
  • Neoplasm Proteins
  • STIM1 protein, human
  • Stromal Interaction Molecule 1
  • MAP Kinase Kinase Kinases
  • Calcium