HECT and RING finger families of E3 ubiquitin ligases at a glance

J Cell Sci. 2012 Feb 1;125(Pt 3):531-7. doi: 10.1242/jcs.091777.

Authors

Meredith B Metzger¹, Ventzislava A Hristova, Allan M Weissman

Affiliation

¹ Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Apoptosis
Cell Cycle Checkpoints
Humans
Models, Biological
Models, Molecular
Neovascularization, Physiologic
Proteasome Endopeptidase Complex / metabolism
Protein Structure, Tertiary
Proto-Oncogene Proteins c-mdm2 / metabolism
RING Finger Domains
Tumor Suppressor Protein p53 / metabolism
Ubiquitin-Protein Ligases / chemistry
Ubiquitin-Protein Ligases / classification
Ubiquitin-Protein Ligases / metabolism*
Ubiquitination

Substances

Tumor Suppressor Protein p53
Proto-Oncogene Proteins c-mdm2
Ubiquitin-Protein Ligases
Proteasome Endopeptidase Complex