Is harassment based on personal characteristics such as race/ethnicity, sexual orientation, religion, or disability more detrimental than general harassment? In 2 large population-based studies of adolescents, more than one third of those harassed reported bias-based school harassment. Both studies show that bias-based harassment is more strongly associated with compromised health than general harassment. Research on harassment among youths rarely examines the underlying cause. Attention to bias or prejudice in harassment and bullying should be incorporated into programs and policies for young people.