Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Jan;96(1):141-54.
doi: 10.1016/j.mcna.2012.01.011.

Childhood cholesterol disorders: the iceberg base or nondisease?

Sarah D de Ferranti  1
Affiliations
Review

Childhood cholesterol disorders: the iceberg base or nondisease?

Sarah D de Ferranti. Med Clin North Am. 2012 Jan.

Abstract

Pediatric cholesterol disorders are common, affecting 1 in 5 adolescents, although most are mild or moderate abnormalities. Because cholesterol values during childhood are moderately predictive of adult cholesterol levels, and are associated with atherosclerosis by pathology and by vascular testing, and because familial hyperlipidemias are associated with early cardiovascular events, cholesterol screening is recommended during childhood. Identified lipid abnormalities are an indication for lifestyle improvement and, in rare cases, pharmacotherapy. However, many gaps in the pediatric knowledge base remain about the benefits and risk, the optimal method for lipid screening, and about appropriate indications for pharmacotherapy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • The differences of lipid profiles between only children and children with siblings: A national survey in China.
    Cai L, Ma B, Lin L, Chen Y, Yang W, Ma J, Jing J. Cai L, et al. Sci Rep. 2019 Feb 5;9(1):1441. doi: 10.1038/s41598-018-37695-0. Sci Rep. 2019. PMID: 30723228 Free PMC article.
  • Prevalence of dyslipidemia in Iranian children and adolescents: A systematic review.
    Hovsepian S, Kelishadi R, Djalalinia S, Farzadfar F, Naderimagham S, Qorbani M. Hovsepian S, et al. J Res Med Sci. 2015 May;20(5):503-21. doi: 10.4103/1735-1995.163979. J Res Med Sci. 2015. PMID: 26487880 Free PMC article. Review.
  • Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta-analysis.
    Cai L, Wu Y, Cheskin LJ, Wilson RF, Wang Y. Cai L, et al. Obes Rev. 2014 Dec;15(12):933-44. doi: 10.1111/obr.12227. Epub 2014 Sep 29. Obes Rev. 2014. PMID: 25263653 Free PMC article. Review.
  • Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
    Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH; LifeLines Cohort Study; Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, B… See abstract for full author list ➔ Asselbergs FW, et al. Am J Hum Genet. 2012 Nov 2;91(5):823-38. doi: 10.1016/j.ajhg.2012.08.032. Epub 2012 Oct 11. Am J Hum Genet. 2012. PMID: 23063622 Free PMC article.

MeSH terms