The potential of interleukin-17 to mediate hematopoietic response

Immunol Res. 2012 Apr;52(1-2):34-41. doi: 10.1007/s12026-012-8276-8.


It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis through stimulation of granulopoiesis and neutrophil trafficking. Furthermore, our data demonstrated that IL-17 also affects other cells of hematopoietic system, such as erythroid progenitors, as well as mesenchymal stem cells. In order to better understand the regulatory role of IL-17 in hematopoiesis, molecular mechanisms underlying the effects of IL-17 on hematopoietic and mesenchymal stem cells were also studied.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells
  • Hematopoiesis*
  • Hematopoietic Stem Cells / physiology
  • Hematopoietic System / metabolism*
  • Humans
  • Interleukin-17 / immunology*
  • Mesenchymal Stem Cells / metabolism
  • Neutrophils / metabolism
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism


  • Interleukin-17