[CARD15 and TLR4 genes polymorphisms in atopic bronchial asthma]

Mol Biol (Mosk). 2011 Sep-Oct;45(5):831-9.
[Article in Russian]


In order to investigate whether single nucleotide polymorphisms G(+2722)C and 3020insC in CARD15 gene and Asp299Gly in TLR4 gene contribute to atopic bronchial asthma we performed a comparative analysis of alleles and genotypes frequencies of these polymorphisms in Russian patients from Moscow. DNA samples from 283 patients with atopic bronchial asthma and 227 healthy donors were genotyped. There were associations neither of G(+2722)C and 3020insC in CARD15 gene and Asp299Gly in TLR4 gene with asthma nor of markers of CARD15 gene with asthma severity. Haplotype frequency analysis of CARD15 gene polymorphisms did not reveal significant difference between groups. However, a strong association was found between Asp299Gly and asthma severity. Allele Asp of this marker showed association with mild atopic bronchial asthma and allele Gl--with moderate/severe asthma = 0.47, 95% CI [0.24-0.93] i OR = 2.12, 95% CI [1.08-4.18] respectively).

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Alleles
  • Asthma / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Moscow
  • Nod2 Signaling Adaptor Protein / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Severity of Illness Index
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Toll-Like Receptor 4 / genetics*


  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein
  • TLR4 protein, human
  • Toll-Like Receptor 4