The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination

Exp Cell Res. 2012 Jul 15;318(12):1340-6. doi: 10.1016/j.yexcr.2012.02.018. Epub 2012 Feb 28.

Abstract

The synaptonemal complex (SC) is a proteinaceous structure of chromosome bivalents whose assembly is indispensable for the successful progression of the first meiotic division of sexually reproducing organisms. In this mini-review we will focus on recent progress dealing with the composition and assembly of the mammalian SC. These advances mainly resulted from the systematic use of knockout mice for all known mammalian SC proteins as well as from protein polymerization studies performed in heterologous systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Mammals / genetics
  • Mammals / metabolism
  • Mammals / physiology*
  • Meiosis / genetics
  • Meiosis / physiology*
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Protein Multimerization / genetics
  • Protein Multimerization / physiology*
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Protein Subunits / physiology
  • Recombination, Genetic / genetics
  • Recombination, Genetic / physiology*
  • Synaptonemal Complex / genetics
  • Synaptonemal Complex / metabolism
  • Synaptonemal Complex / physiology*

Substances

  • Protein Subunits