Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors

Nanoscale. 2012 Apr 7;4(7):2352-61. doi: 10.1039/c2nr11554a. Epub 2012 Mar 6.

Abstract

Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333-20,000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (M(w)) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating M(w) of 10,000 Da.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Coated Materials, Biocompatible / chemistry
  • Coated Materials, Biocompatible / pharmacokinetics*
  • Contrast Media / chemistry
  • Contrast Media / pharmacokinetics
  • Drug Delivery Systems
  • Ferric Compounds / chemistry
  • Ferric Compounds / pharmacokinetics*
  • Magnetics
  • Metal Nanoparticles / chemistry
  • Mice
  • Mice, Inbred C3H
  • Models, Biological
  • Molecular Weight
  • Neoplasms / diagnosis
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Oleic Acid / chemistry
  • Oleic Acid / pharmacokinetics
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacokinetics*
  • Silanes / chemistry
  • Silanes / pharmacokinetics
  • Tissue Distribution

Substances

  • Coated Materials, Biocompatible
  • Contrast Media
  • Ferric Compounds
  • Silanes
  • ferric oxide
  • Oleic Acid
  • Polyethylene Glycols