Deep peeling using phenol versus percutaneous collagen induction combined with trichloroacetic acid 20% in atrophic post-acne scars; a randomized controlled trial

J Dermatolog Treat. 2014 Apr;25(2):130-6. doi: 10.3109/09546634.2012.674192. Epub 2012 May 8.

Abstract

Background: Deep peeling using phenol and percutaneous collagen induction (PCI) are used in treating acne scars.

Aim: To compare deep peeling using phenol and PCI combined with trichloroacetic acid (TCA) 20% in treating atrophic acne scars.

Methods: 24 patients with post-acne atrophic scars were randomly divided into two groups; group 1 was subjected to one session of deep peeling using phenol, and group 2 was subjected to four sessions of PCI combined with TCA 20%. As a secondary outcome measure, side effects were recorded and patients were asked to assess their % of improvement by a questionnaire completed 8 months after the procedure.

Results: Scar severity scores improved by a mean of 75.12% (p < 0.001) in group 1 and a mean of 69.43% (p < 0.001) in group 2. Comparing the degree of improvement in different types of scars, within the same group after treatment, revealed a significant highest degree of improvement in the rolling type (p = 0.005) in group 2.

Conclusion: Deep peeling using phenol and PCI with TCA 20% were effective in treating post-acne atrophic scars.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / physiopathology
  • Chemexfoliation
  • Cicatrix / etiology
  • Cicatrix / metabolism
  • Cicatrix / therapy*
  • Collagen / physiology
  • Cosmetic Techniques* / instrumentation
  • Female
  • Humans
  • Keratolytic Agents / administration & dosage*
  • Male
  • Needles
  • Phenol / administration & dosage*
  • Single-Blind Method
  • Skin / physiopathology
  • Trichloroacetic Acid / administration & dosage*
  • Young Adult

Substances

  • Keratolytic Agents
  • Phenol
  • Trichloroacetic Acid
  • Collagen