The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?

Hypertens Res. 2012 May;35(5):477-84. doi: 10.1038/hr.2012.30. Epub 2012 Mar 8.


The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke. SHRSP, as well as the spontaneously hypertensive rat, the parental strain of SHRSP, has made a tremendous contribution to cardiovascular research. However, the genetic mechanisms underlying hypertension and stroke in these rats have not yet been clarified. Recent studies using whole-genome sequencing and comprehensive gene expression analyses combined with classical quantitative trait loci analyses provided several candidate genes, such as Ephx2, Gstm1 and Slc34a1, which still need further evidence to define their pathological roles. Currently, genome-wide association studies can directly identify candidate genes for hypertension in the human genome. Thus, genetic studies in SHRSP and other rat models must be focused on the pathogenetic roles of 'networks of interacting genes' in hypertension, instead of searching for individual candidate genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD36 Antigens / genetics
  • Epoxide Hydrolases / genetics
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study*
  • Glutathione Transferase / genetics
  • Humans
  • Hypertension / genetics
  • Male
  • Models, Genetic
  • Quantitative Trait Loci / genetics
  • Rats
  • Rats, Inbred SHR / genetics*
  • Rats, Inbred WKY
  • Sodium-Phosphate Cotransporter Proteins, Type IIa / genetics
  • Stroke / genetics*
  • Sympathetic Nervous System


  • CD36 Antigens
  • Slc34a1 protein, rat
  • Sodium-Phosphate Cotransporter Proteins, Type IIa
  • Glutathione Transferase
  • glutathione S-transferase M1
  • Epoxide Hydrolases
  • EPHX2 protein, rat