A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome

J Pediatr. 2012 Jun;160(6):1055-7. doi: 10.1016/j.jpeds.2012.01.056. Epub 2012 Mar 7.


We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Child
  • Diagnosis, Differential
  • Follow-Up Studies
  • Humans
  • Immunologic Deficiency Syndromes / diagnosis
  • Immunologic Deficiency Syndromes / enzymology*
  • Job Syndrome / diagnosis
  • Magnetic Resonance Imaging
  • Male
  • TYK2 Kinase / blood
  • TYK2 Kinase / deficiency*


  • TYK2 Kinase