Relationship of oxygen dose to angiogenesis induction in irradiated tissue

Am J Surg. 1990 Nov;160(5):519-24. doi: 10.1016/s0002-9610(05)81019-0.


This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Air
  • Animals
  • Atmospheric Pressure
  • Collateral Circulation* / drug effects
  • Hyperbaric Oxygenation
  • Male
  • Oxygen / administration & dosage*
  • Oxygen / pharmacology
  • Rabbits
  • Radiation Injuries, Experimental / drug therapy*
  • Radiation Injuries, Experimental / physiopathology


  • Oxygen