Microbes and the gut-brain axis

Neurogastroenterol Motil. 2012 May;24(5):405-13. doi: 10.1111/j.1365-2982.2012.01906.x. Epub 2012 Mar 8.

Abstract

Background: The 'gut-brain' or 'brain-gut axis', depending on whether we emphasize bottom-up or top-bottom pathways, is a bi-directional communication system, comprised of neural pathways, such as the enteric nervous system (ENS), vagus, sympathetic and spinal nerves, and humoral pathways, which include cytokines, hormones, and neuropeptides as signaling molecules. Recent evidence, mainly arising from animal models, supports a role of microbes as signaling components in the gut-brain axis.

Aims: The purpose of this review is to summarize our current knowledge regarding the role of microbes, including commensals, probiotics and gastrointestinal pathogens, in bottom-up pathways of communication in the gut-brain axis. Although this has clear implications for psychiatric co-morbidity in functional and inflammatory conditions of the gut, the focus of this review will be to discuss the current evidence for a role of bacteria (commensals, probiotics, and pathogens) as key modulators of gut-brain communication.

Results & conclusions: The strongest evidence for a role of microbes as signaling components in the gut-brain axis currently arises from animal studies and indicate that mechanisms of communication are likely to be multiple. There is need for the concepts generated in animal models to be translated to the human in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / microbiology*
  • Central Nervous System / microbiology
  • Central Nervous System / physiology
  • Enteric Nervous System / physiology
  • Gastrointestinal Tract / innervation*
  • Gastrointestinal Tract / microbiology*
  • Homeostasis / physiology
  • Humans
  • Intestines / microbiology
  • Mice
  • Probiotics