Ob-stopping obesity, metabolic and immune-mediated disorders

Giuseppe Matarese; Veronica De Rosa

doi:10.1016/j.str.2012.02.005

Ob-stopping obesity, metabolic and immune-mediated disorders

Structure. 2012 Mar 7;20(3):385-7. doi: 10.1016/j.str.2012.02.005.

Authors

Giuseppe Matarese¹, Veronica De Rosa

Affiliation

¹ Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universitá di Napoli Federico II, Napoli 80131, Italy. gmatarese@unisa.it

PMID: 22404995
DOI: 10.1016/j.str.2012.02.005

Abstract

Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb).

Publication types

Comment

Grants and funding

GJT08004/TI_/Telethon/Italy